CSIR NET Life Science Syllabus , Application Form , Eligibility Criteria , Pattern , Exam Date 2023

CSIR NET Life Science Syllabus , Application Form , Eligibility Criteria , Pattern , Exam Date 2023

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CSIR-NET Exam Application form Released Date  : 10 March 2023

Last Date for submission of the application form : 10 April 2023

Admit Card Release : May 2023

CSIR-NET Exam Date : 06 – 08 June 2023

Conduct Agency : NTA (National Testing Agency )

CSIR-NET Exam Pattern : Online Mode 

CSIR-NET Exam Result : July – August 2023 

The Validity of CSIR-NET Exam Score Card : 2 Years ( Effective from the Date Mentioned in NET Certificate ) 

CSIR NET Life Science Syllabus

CSIR-NET Exam Eligibility Criteria : –

The condinates who qualify in CSIR-NET Exam shall have to fullfill the following Eligibility Requirement for Application form.

  • M.sc / Equivalent Degree with 55 % Marks for General / OBC Candidates.
  • For SC / ST and PH Candidates 50 % Marks .
  • Intregrated Course and B.E / B.Tech / B.Pharma and MBBS Candidates are also Eligible for CSIR-NET Exam 2023.
CSIR-NET Exam Age Limit & Relaxation :- 
  • For JRF (NET) : Maximum 28 years ( upper age limit may be relaxable up to 5 years in case of SC / ST / Persons with Disability (PWD) / female applicants and 03 years in case of OBC (Non – Creamy Layer) Applicants.
  • For Lectureship ( NET ) : No upper Age limit.
CSIR-NET Exam Pattern : – 
  • CSIR-NET Exam will conducted Online Mode(CBT) .
  • Duration of  Exam will be 3 hours.
  • The Paper will be asked in the English Language & Hindi Only .
  • Section : 3 Sections ( Section – A , Section – B , Section – C ).
  • Number of Questions : 120 Questions 
  • Total Marks : 200 Marks.
CSIR-NET Exam Marking Pattern of the Paper :-

The examination is of  3 hours duration , There are a total 120 Questions carrying 200 Marks. The entire paper is divided into three Part- A , B and C . All sections are compulsory. Questions in each section are of different types.

  • PART – A contains a Maximum of 20 Question of General Aptitude out of which only 15 Questions will be taken up for Evaluation. Each question carries 2 marks with negative marking of 0.5 marks.
  • PART – B shall contain subject – related conventional MCQs. This part contains a maximum of 40 Questions out of which only 25 questions will be taken up for evalution. Each question carries 3 marks with negative marking of 0.75 marks.
  • PART – C shall contain subject-related conventional MSQs. This part contains a maximum of 60 Questions out of which only 20 Questions will be taken up for Evaluation. Each question carries 4.75 marks with no negative marking.
  • In all Parts , Questions not attempted will resulit in zero mark .

5. Only Virtual Scientific Calculator is allowed . Charts , Graph Sheets , Tables , Cellular Phone or Other Electronic Gadgets are NOT allowes in the examination hall.

Particulars Part – A Part – B Part – C Total
Total Questions 20 40 60 120
Maximum questions to be attempted 15 25 20 75
Marks for each correct answer + 2 + 3 + 4.75
Maximum Marks 30 75 95 200
Marks for each incorrect answer – 0.5 – 0.75 0


Syllabus for Life Science : – 

Molecules and their Interaction Relevant to Biology :-

  • Structure of atoms, molecules and chemical bonds.
  • Composition, structure and function of biomolecules (carbohydrates, lipids, proteins, nucleic acids and vitamins).
  • Stablizing interactions (Vander Waals, electrostatic, hydrogen bonding, hydrophobic interaction, etc.).
  • Principles of biophysical chemistry (pH, buffer, reaction kinetics, thermodynamics, colligative properties).
  • Bioenergetics, glycolysis, oxidative phosphorylation, coupled reaction, group transfer, biological energy transducers.
  • Principles of catalysis, enzymes and enzyme kinetics, enzyme regulation, mechanism of enzyme catalysis, isozymes.
  • Conformation of proteins (Ramachandran plot, secondary structure, domains, motif and folds).
  • Conformation of nucleic acids (helix (A, B, Z), t-RNA, micro-RNA).
  • Stability of proteins and nucleic acids.
  • Metabolism of carbohydrates, lipids, amino acids nucleotides and vitamins.

Cellular Organization :-

  • Membrane structure and function : (Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, membrane pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes).
  • Structural organization and function of intracellular organelles : (Cell wall, nucleus, mitochondria, Golgi bodies, lysosomes, endoplasmic reticulum, peroxisomes, plastids, vacuoles, chloroplast, structure & function of cytoskeleton and its role in motility).
  • Organization of genes and chromosomes : (Operon, unique and repetitive DNA, interrupted genes, gene families, structure of chromatin and chromosomes, heterochromatin, euchromatin, transposons).
  • Cell division and cell cycle : (Mitosis and meiosis, their regulation, steps in cell cycle, regulation and control of cell cycle).
  • Microbial Physiology : (Growth yield  and  characteristics,  strategies  of  cell  division, stress response) .

 Fundamental Processes :-

  • DNA replication, repair and recombination (Unit of replication, enzymes involved, replication origin and replication fork, fidelity of replication, extrachromosomal replicons, DNA damage and repair mechanisms, homologous and site-specific recombination).
  • RNA synthesis and processing (transcription factors and machinery, formation of initiation complex, transcription activator and repressor, RNA polymerases, capping, elongation, and termination, RNA processing, RNA editing, splicing, and polyadenylation, structure and function of different types of RNA, RNA transport).
  • Protein synthesis and processing (Ribosome, formation of initiation complex, initiation factors and their regulation, elongation and elongation factors, termination, genetic code, aminoacylation of tRNA, tRNA-identity, aminoacyl tRNA synthetase, and translational proof-reading, translational inhibitors, Post- translational modification of proteins).
  • Control of gene expression at transcription and translation level (regulating the expression of phages, viruses, prokaryotic and eukaryotic genes, role of chromatin in gene expression and gene silencing).

Cell communication and cell signaling :-

  • Host parasite interaction : Recognition and   entry  processes  of  different pathogens like bacteria, viruses into animal and plant host cells, alteration of host cell behavior by pathogens, virus-induced cell transformation, pathogen-induced diseases in animals and plants, cell-cell fusion in both normal and abnormal cells.
  • Cell signaling : Hormones and their receptors, cell surface receptor, signaling through G-protein coupled receptors, signal transduction pathways, second messengers, regulation   of   signaling   pathways,   bacterial   and   plant   two- component systems, light signaling in plants, bacterial chemotaxis and quorum sensing.
  • Cellular communication : Regulation of hematopoiesis, general principles of cell communication, cell adhesion and roles of different adhesion molecules, gap junctions, extracellular matrix, integrins, neurotransmission and its regulation.
  • Cancer : Genetic rearrangements in progenitor cells, oncogenes, tumor suppressor genes, cancer and the cell cycle, virus-induced cancer, metastasis, interaction of cancer cells with normal cells, apoptosis, therapeutic interventions of uncontrolled cell growth.
  • Innate and adaptive immune system : Cells and molecules involved in innate and adaptive immunity, antigens, antigenicity and immunogenicity. B and T cell epitopes,  structure and function of antibody molecules. generation of antibody diversity, monoclonal antibodies, antibody engineering, antigen-antibody interactions, MHC molecules, antigen processing and presentation, activation and differentiation of B and T cells, B and T   cell receptors, humoral and cell- mediated immune responses, primary and secondary immune modulation, the complement system, Toll-like receptors, cell-mediated effector functions, inflammation, hypersensitivity and autoimmunity, immune response during bacterial (tuberculosis), parasitic (malaria) and viral (HIV) infections, congenital and acquired immunodeficiencies, vaccines.

 Developmental Biology :-

  • Basic concepts   of   development   :   Potency,   commitment,   specification,   induction, competence, determination and differentiation; morphogenetic gradients; cell fate and cell lineages; stem cells; genomic equivalence and the cytoplasmic determinants; imprinting; mutants and transgenics in analysis of development .
  • Gametogenesis, fertilization and early development : Production of gametes, cell surface molecules in sperm-egg recognition in animals; embryo sac development and double fertilization in plants; zygote formation, cleavage, blastula formation, embryonic fields, gastrulation and formation of germ layers in animals; embryogenesis, establishment of symmetry in plants; seed formation and germination.
  • Morphogenesis and organogenesis in animals : Cell aggregation and differentiation in Dictyostelium; axes and pattern formation in Drosophila, amphibia and chick; organogenesis – vulva formation in Caenorhabditis elegans, eye lens induction, limb development and regeneration in vertebrates; differentiation of neurons, post embryonic development- larval formation, metamorphosis; environmental regulation of normal development; sex determination.
  • Morphogenesis and organogenesis in plants : Organization of shoot and root apical meristem; shoot and root development; leaf development and phyllotaxy; transition to flowering, floral meristems and floral development in Arabidopsis and Antirrhinum .
  • Programmed cell death, aging and senescence .

System Physiology – Plant :-

  • Photosynthesis : Light   harvesting   complexes;   mechanisms   of electron transport; photoprotective mechanisms; COfixation – C3 , C4 and CAM pathways.
  • Respiration and photorespiration  :  Citric  acid  cycle;  plant  mitochondrial electron transport and ATP synthesis; alternate oxidase; photorespiratory pathway.
  • Nitrogen metabolism : Nitrate and ammonium  assimilation;  amino  acid biosynthesis.
  • Plant hormones : Biosynthesis, storage, breakdown and transport; physiological effects and mechanisms of action.
  • Sensory photobiology : Structure, function  and  mechanisms  of phytochromes, cryptochromes and phototropins ; stomatal movement; photoperiodism and biological clocks.
  • Solute transport and photo assimilate translocation : uptake, transport and translocation of water, ions, solutes and macromolecules from soil, through cells, across membranes, through xylem and phloem; transpiration; mechanisms of loading and unloading of photoassimilates.
  • Secondary metabolites : Biosynthesis of terpenes, phenols and nitrogenous compounds and their roles.
  • Stress physiology : Responses of plants to biotic (pathogen and insects) and abiotic (water, temperature and salt) stresses.

 System Physiology – Animal :-

  • Blood and circulation : Blood corpuscles, haemopoiesis and formed elements, plasma function, blood volume, blood volume regulation, blood groups, haemoglobin, immunity, haemostasis.
  • Cardiovascular System : Comparative anatomy of heart structure, myogenic heart, specialized tissue, ECG – its principle and significance, cardiac cycle, heart as a pump, blood pressure, neural and chemical regulation of all above.
  • Respiratory system : Comparison of respiration in different species, anatomical considerations, transport of gases, exchange of gases, waste elimination, neural and chemical regulation of respiration.
  • Nervous system : Neurons, action potential, gross neuroanatomy of the brain and spinal cord, central and peripheral nervous system, neural control of muscle tone and posture.
  • Sense organs : Vision, hearing and tactile response.
  • Excretory system  :  Comparative   physiology  of   excretion,  kidney,  urine formation, urine concentration, waste elimination, micturition,  regulation of water balance, blood volume, blood pressure, electrolyte balance, acid-base balance.
  • Thermoregulation : Comfort  zone,  body  temperature  –  physical,  chemical, neural regulation, acclimatization.
  • Stress and adaptation
  • Digestive system : Digestion, absorption, energy balance, BMR.
  • Endocrinology and reproduction : Endocrine glands, basic mechanism of hormone action, hormones and diseases; reproductive processes, gametogenesis, ovulation, neuroendocrine regulation .

Inheritance Biology :-

  • Mendelian principles : Dominance, segregation, independent assortment.
  • Concept of gene : Allele, multiple alleles, pseudoallele, complementation tests
  • Extensions of Mendelian principles : Codominance, incomplete dominance, gene interactions, pleiotropy,  genomic  imprinting,  penetrance  and  expressivity,  phenocopy, linkage and crossing over, sex linkage, sex limited and sex influenced characters.
  • Gene mapping methods : Linkage maps, tetrad analysis, mapping with molecular markers, mapping by using somatic cell hybrids, development of mapping population in plants.
  • Extra chromosomal inheritance : Inheritance of Mitochondrial and chloroplast genes, maternal inheritance.
  • Microbial genetics : Methods of genetic transfers – transformation, conjugation, transduction and sex-duction, mapping genes by interrupted mating, fine structure analysis of genes.
  • Human genetics : Pedigree analysis, lod score for linkage testing, karyotypes, genetic disorders.
  • Quantitative genetics  :  Polygenic  inheritance,  heritability  and  its  measurements,  QTL mapping.
  • Mutation : Types, causes and detection, mutant types – lethal, conditional, biochemical, loss of function, gain of function, germinal verses somatic mutants, insertional mutagenesis.
  • Structural and numerical alterations of chromosomes : Deletion, duplication, inversion, translocation, ploidy and their genetic implications.
  • Recombination : Homologous and non-homologous recombination including transposition.

Diversity of Life Forms  :-

  • Principles & methods of taxonomy: Concepts of species and hierarchical taxa, biological nomenclature, classical & quantitative methods of taxonomy of plants, animals and microorganisms.
  • Levels of structural organization: Unicellular, colonial and multicellular forms. Levels of organization of tissues, organs & systems.  Comparative anatomy, adaptive radiation, adaptive modifications.
  • Outline classification of plants, animals & microorganisms : Important criteria used for classification in each taxon.Classification of plants, animals and microorganisms.  Evolutionary relationships among taxa.
  • Natural history of Indian subcontinent : Major habitat types of the subcontinent, geographic origins and migrations of species. Common Indian mammals, birds.  Seasonality and phenology of the subcontinent.
  • Organisms of health & agricultural importance : Common parasites and pathogens of humans, domestic animals and crops.
  • Organisms of conservation concern : Rare, endangered species. Conservation strategies.

Ecological Principles :-

  • The Environment : Physical environment ;  biotic   environment;   biotic   and   abiotic interactions.
  • Habitat and Niche : Concept of habitat and niche; niche width and overlap; fundamental and realized niche; resource partitioning; character displacement.
  • Population Ecology : Characteristics of a population; population growth curves; population regulation; life history strategies (r andK selection); concept of metapopulation – demes and dispersal, interdemic extinctions, age structured populations.
  • Species Interactions : Types of interactions, interspecific competition, herbivory, carnivory, pollination, symbiosis.
  • Community Ecology : Nature  of  communities;  community  structure  and  attributes; levels of species diversity and its measurement; edges and ecotones.
  • Ecological Succession : Types; mechanisms; changes involved in succession; concept of climax.
  • Ecosystem Ecology : Ecosystem  structure;  ecosystem  function;  energy  flow  and mineral cycling (C,N,P); primary production and decomposition; structure and function of some Indian ecosystems: terrestrial (forest, grassland) and aquatic (fresh water, marine, estuarine).
  • Biogeography : Major  terrestrial  biomes;  theory  of  island  biogeography; biogeographical zones of India.
  • Applied Ecology : Environmental pollution; global environmental change; biodiversity: status, monitoring and documentation; major drivers of biodiversity change; biodiversity management approaches.
  • Conservation Biology : Principles of conservation, major approaches to management, Indian case studies on conservation/management strategy (Project Tiger, Biosphere reserves).

Evolution and Behavior :-

Emergence of evolutionary thoughts :

  • Lamarck; Darwin–concepts of variation, adaptation, struggle, fitness and natural selection; Mendelism; Spontaneity of mutations; The evolutionary synthesis.

Origin of cells and unicellular evolution :

  • Origin of basic biological molecules; Abiotic synthesis of organic monomers and polymers; Concept of Oparin and Haldane; Experiment of Miller (1953); The first cell; Evolution of prokaryotes; Origin of eukaryotic cells; Evolution of unicellular eukaryotes; Anaerobic metabolism, photosynthesis and aerobic metabolism.

Paleontology and Evolutionary History :

  • The evolutionary time scale; Eras, periods and epoch; Major events in the evolutionary time scale; Origins of unicellular and multi cellular organisms; Major groups of plants and animals; Stages in primate evolution including 

Molecular Evolution :

  • Concepts of neutral evolution, molecular divergence and molecular clocks; Molecular tools in phylogeny, classification and identification; Protein and nucleotide sequence analysis; origin of new genes and proteins; Gene duplication and divergence.

The Mechanisms :

  • Population genetics – Populations, Gene pool, Gene frequency; Hardy-Weinberg Law; concepts and rate of change in gene frequency through natural selection, migration and random genetic drift; Adaptive radiation; Isolating mechanisms; Speciation; Allopatricity and Sympatricity; Convergent evolution; Sexual  selection; Co-evolution.

Brain, Behaviour and Evolution:

  • Approaches and  methods  in  study  of  behavior;  Proximate  and  ultimate  causation; Altruism and evolution-Group selection, Kin selection, Reciprocal altruism; Neural basis of  learning,  memory,  cognition,  sleep  and  arousal;  Biological  clocks;  Development of behavior; Social communication; Social dominance; Use of space and territoriality; Mating  systems,   Parental  investment  and   Reproductive   success; Parental   care; Aggressive behavior; Habitat selection and optimality in foraging; Migration, orientation and navigation; Domestication and behavioral changes.

Applied Biology : –

  • Microbial fermentation and production of small and macro molecules.
  • Application of immunological principles, vaccines, diagnostics. Tissue and cell  culture methods for plants and animals.
  • Transgenic animals and plants, molecular approaches to diagnosis and strain identification.
  • Genomics and its application to health and agriculture, including gene therapy.
  • Bioresource and uses of biodiversity.
  • Breeding in plants and animals, including marker – assisted selection .
  • Bioremediation and phytoremediation.
  • Biosensors .

Methods in Biology :-

Molecular Biology and Recombinant DNA methods :

  • Isolation and purification of RNA , DNA (genomic and plasmid) and proteins, different separation methods.
  • Analysis of RNA, DNA and proteins by one- and two-dimensional gel electrophoresis, Isoelectric focusing gels.
  • Molecular cloning of DNA or RNA fragments in bacterial and eukaryotic
  • Expression of recombinant proteins using bacterial, animal and plant vectors. Isolation of specific nucleic acid sequences.
  • Generation of genomic and cDNA libraries in plasmid, phage, cosmid, BAC and YAC vectors.
  • In vitro mutagenesis and deletion techniques, gene knock out in bacterial and eukaryotic organisms.
  • Protein sequencing methods, detection of post translation modification of proteins.
  • DNA sequencing methods, strategies for genome sequencing. Methods for analysis of gene expression at RNA and protein level, large scale expression, such as micro array based techniques.
  • Isolation, separation and analysis of carbohydrate and lipid molecules RFLP, RAPD and AFLP techniques.

Histochemical and Immunotechniques :

  • Antibody generation, Detection of molecules using ELISA, RIA, western blot, immunoprecipitation, fluocytometry and immunofluorescence microscopy, detection of molecules in living cells, in situ localization by techniques such as FISH and GISH.

Biophysical Method :

  • Molecular analysis using UV/visible, fluorescence, circular dichroism, NMR and ESR spectroscopy  Molecular  structure  determination  using  X-ray  diffraction  and  NMR, Molecular analysis using light scattering, different types of mass spectrometry and surface plasma resonance 

Statisitcal Methods :

  • Measures of   central   tendency  and   dispersal;   probability  distributions   (Binomial, Poisson and normal); Sampling distribution; Difference between parametric and non-parametric   statistics;      Confidence   Interval;   Errors;   Levels   of   significance; Regression      and  Correlation; t-test; Analysis of variance; Xtest;; Basic introduction to Muetrovariate statistics, etc.

Radiolabeling techniques :

  • Detection and  measurement  of  different  types  of  radioisotopes  normally  used  in biology,  incorporation  of  radioisotopes  in  biological  tissues  and  cells,  molecular imaging of radioactive material, safety guidelines.

Microscopic techniques :

  • Visulization of cells and subcellular components by light microscopy, resolving powers of different microscopes, microscopy of living cells, scanning and transmission microscopes, different fixation and staining techniques for EM, freeze-etch and freeze- fracture methods for EM, image processing methods in microscopy.

Electrophysiological methods:

  • Single neuron recording, patch-clamp recording, ECG, Brain activity recording, lesion and stimulation of brain, pharmacological testing, PET, MRI, fMRI, CAT .

Methods in field biology :

  • Methods of estimating population density of animals and plants, ranging patterns through direct, indirect and remote observations, sampling methods in the study of behavior, habitat characterization: ground and remote sensing methods.
CSIR NET Life Science Syllabus Download :- 
CSIR-NET Life Science Syllabus



CSIR-NET Exam Application Fees : –
  • General Category can apply for the examination fees Rs.1100 / – only. 
  • OBC Category can apply for the examination fees Rs.550 / – only. 
  • SC / ST Category can apply for the examination fees Rs.275 / – only. 
  • Pwd Category can apply for the examination fees zero .
Steps To Check CSIR-NET Exam Result :-
  • Visit the Official Website of CSIR-NET Exam 2023 i.e,  csirnet.nta.nic.in
  • On the Home Page, Search for the CSIR-NET Exam Result.
  • Then click on the Result link.
  • Enter your Email ID and Password.
  • Then click on the Submit Button.
  • Check the Result.
  • Download and take the Printout of the Result.
Junior Research Fellowship Stipend :-
  • The Stipend of JRF selected through CSIR-UGC National Eligibility Test (NET) will be Rs. 25000 / P.m. for the first two years.
  • In addition , annual contingency grant Rs. 20000 /- per follow will be provided to the University / Institution. The Fellowship will be governed by terms and conditions of CSIR , UGC or Research Scheme , as Applicable.
  • On Completion of two years as JRF and if the Fellow is registered for P.HD, the Fellowship will be upgraded to SRF asssessment of Fellows research progress / achievements through Interview by an Expert Committee consisting of the Guide . Head of the Department and External Member from outside the University Institution who is an Expert in the relevant field , not below the rank of Professor / Associate Professor. 

Question : When is the CSIR-NET EXAM ?

Answer : The CSIR-NET Exam will be held in June 2023.

Question : When will the CSIR-NET Online application process start ? 

Answer : The CSIR-NET online application from has been released on 10 March 2023 on the official website of CSIR-NET NTA.

Question : What is the last date of submission for the CSIR-NET application form ? 

Answer : The last date of submission of the CSIR-NET online application from is (Extended till 17 April 2023 ).

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